Drug Interactions With Protein-Bound Paclitaxel

Among the medicines that may potentially cause drug interactions with protein-bound paclitaxel are rifamycin antibiotics, certain anticonvulsants, "live" vaccinations, and certain antibiotics or antifungals. These protein-bound paclitaxel drug interactions may affect the levels of some medicines in your blood and increase your risk of developing side effects.

 

An Overview of Drug Interactions With Protein-Bound Paclitaxel

Protein-bound paclitaxel (Abraxane®) can potentially interact with certain other medications. Some of these medicines that may lead to protein-bound paclitaxel interactions include:
 
  • Certain antibiotics or antifungals, including:

 

    • Clarithromycin (Biaxin®)
    • Erythromycin (Ery-Tab®)
    • Isoniazid (Nydrazid®)
    • Itraconazole (Sporanox®)
    • Ketoconazole (Nizoral®)
    • Miconazole
    • Telithromycin (Ketek®)

 

  • Certain anticonvulsants, including:

 

 

  • "Live" vaccinations, including:

 

 

  • Rifamycin antibiotics, including rifabutin (Mycobutin®), rifampin (Rifadin®), and rifapentine (Priftin®).
     
(Drug Interactions With Protein-Bound Paclitaxel Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;