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Side Effects of Propoxyphene Napsylate

Notify your healthcare provider right away if you develop potentially serious propoxyphene napsylate side effects, such as seizures, hallucinations, or difficulty breathing. However, in most cases, people do not experience any problems and if reactions do occur, they are typically easy to treat. Other possible side effects may include nausea, vomiting, and dizziness.

An Introduction to Propoxyphene Napsylate Side Effects

In November 2010, the United States Food and Drug Administration (FDA) withdrew all medications that contain propoxyphene from the market. It has been determined that the risks of propoxyphene outweigh the possible benefits. In particular, the FDA was concerned about the drug's ability to cause serious changes in the heart rhythm, even at normal doses. Pharmacies will no longer sell this medication, and people who take it should stop and ask their healthcare provider for a more suitable pain medication.
Just like any medicine, propoxyphene napsylate (Darvon-N®) can cause side effects. However, not everyone who uses the medication will have problems. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider. However, serious reactions have been known to occur.
(This article covers many, but not all, of the possible side effects with propoxyphene napsylate. Your healthcare provider can discuss a more complete list with you.)

Side Effects of Propoxyphene Napsylate to Report

Some propoxyphene napsylate side effects are potentially serious -- even life-threatening -- and should be reported immediately to your healthcare provider. These include but are not limited to:
  • Signs of liver damage, such as:
    • Yellowing of the whites of the eyes or skin (jaundice)
    • Dark urine
    • Upper-right abdominal pain (stomach pain)
  • Hallucinations
  • Confusion
  • Seizures
  • Slow or irregular breathing
  • Unexplained, unpleasant feelings (dysphoria) or unexplained, pleasant feelings (euphoria)
  • The urge to take more propoxyphene napsylate than prescribed or for a nonmedical purpose
  • Low blood pressure (hypotension)
  • An irregular heart rhythm (arrhythmia)
  • Signs of an allergic reaction, such as:
    • An unexplained rash
    • Itching
    • Hives
    • Swelling of the mouth or throat
    • Wheezing
    • Difficulty breathing.
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Propoxyphene Napsylate Drug Information

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