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Drug Interactions With Propoxyphene Napsylate

Drug Interactions With Propoxyphene Napsylate Explained

The following sections explain in detail the potentially negative interactions that can occur when propoxyphene napsylate is combined with any of the drugs listed above.
 
Alcohol
You should avoid drinking alcohol while taking propoxyphene napsylate. Alcohol interacts with this pain medicine, potentially increasing the risk of serious side effects, such as extreme drowsiness, confusion, memory loss, or difficulty breathing (see Darvon-N and Alcohol for more information).
 
Carbamazepine
Propoxyphene napsylate may increase the level of carbamazepine in your blood, perhaps increasing your risk of side effects of carbamazepine (including dangerous side effects). Your healthcare provider may recommend a different pain medication or may decide to decrease your carbamazepine dosage to avoid this drug interaction.
 
Certain Beta Blockers
Propoxyphene napsylate may increase the level of certain beta blockers in your blood. This may increase the chance of beta blocker side effects, such as low blood pressure (hypotension) or a low heart rate (bradycardia). Check with your healthcare provider before taking propoxyphene napsylate with a beta blocker.
 
CYP 3A4 Inducers
The liver metabolizes (breaks down) propoxyphene napsylate using an enzyme known as CYP 3A4. Some medications, known as CYP 3A4 inducers, increase the activity of this enzyme. Taking propoxyphene napsylate with a CYP 3A4 inducer may decrease the level of propoxyphene napsylate in the blood, possibly making it much less effective. Check with your healthcare provider before taking these drugs together.
 
CYP 3A4 Inhibitors
The liver metabolizes (breaks down) propoxyphene napsylate using an enzyme known as CYP 3A4. Some medications, known as CYP 3A4 inhibitors, decrease the activity of this enzyme. Taking propoxyphene napsylate with a strong CYP 3A4 inhibitor may increase the level of propoxyphene napsylate in the blood, increasing the risk of dangerous side effects of propoxyphene napsylate. Check with your healthcare provider before taking these drugs together.
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Propoxyphene Napsylate Drug Information

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