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What Is Ponatinib Used For?

How Does This Medicine Work?

Ponatinib belongs to a group of medicines known as tyrosine kinase inhibitors. Tyrosine kinases are proteins found in the body that control cell function, including cell growth. Ponatinib works by blocking the signal of certain tyrosine kinases, including but not limited to:
  • A mutated kinase known as T315I mutant ABL
  • A kinase that is resistant to treatment with other tyrosine kinase inhibitors.
By inhibiting the activity of T315I mutant ABL and other kinases, ponatinib slows down or stops the production of the abnormal blood cells.

Can Children Use It?

Ponatinib is not approved for use in individuals younger than 18 years old, as it has not been adequately studied in this age group. Talk to your child's healthcare provider about the risks and benefits of using ponatinib in children.

Is It Safe for Older Adults to Use Ponatinib?

Yes, older adults can use this medicine. However, some older adults may be more sensitive to ponatinib side effects and may need to be monitored more closely.

What About Off-Label Ponatinib Uses?

On occasion, your healthcare provider may recommend this medication for treating something other than the conditions discussed in this article. This is called an "off-label" use. At this time, there are no universally accepted off-label ponatinib uses.
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