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Drug Interactions With Ponatinib

More Detail on Drug Interactions With Ponatinib

The following sections explain in detail the potentially negative interactions that can occur when ponatinib is combined with any of the drugs listed above.
 
Antacids
Stomach acid is needed to absorb ponatinib from the stomach into the bloodstream. Medicines that reduce stomach acid can reduce ponatinib blood levels. You can take ponatinib with antacids, just make sure to separate the doses by at least two hours.
 
CYP 3A4 Inducer Medications
The liver breaks down ponatinib using enzymes known as CYP 3A4 enzymes, and medications known as CYP 3A4 inducers can increase the activity of these enzymes. Thus, combining ponatinib with one of these drugs may decrease the amount of ponatinib in your body, potentially making it less effective. Ponatinib should not be taken with certain CYP 3A4 inducers. Your healthcare provider can tell you which medicines are safe to take.
 
CYP 3A4 Inhibitor Medications
The liver breaks down ponatinib using enzymes known as CYP 3A4 enzymes, and medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. Thus, combining ponatinib with one of these drugs may increase the amount of ponatinib in your body, increasing your risk for serious side effects. Ponatinib should not be taken with certain CYP 3A4 inhibitors. Your healthcare provider can tell you which medicines are safe to take.
 
H2 Blockers
Ponatinib is best absorbed in the presence of stomach acid. Medications that reduce stomach acid, including H2 blockers, may decrease the amount of ponatinib absorbed from the stomach into the bloodstream. If you must take an H2 blocker, make sure to separate it from ponatinib by several hours (at least two, although longer is probably preferable).
 
Proton Pump Inhibitors (PPIs)
Stomach acid is needed to absorb ponatinib from the stomach into the bloodstream. Medicines that reduce stomach acid, including PPIs, can reduce ponatinib blood levels. Do not take these medicines together.
 
P-gp Substrates or ABCG2 Substrates
P-gp and ABCG2 are natural proteins that help remove substances, such as medications, from the cells in the body. Ponatinib inhibits these proteins and may affect drugs that are affected by these proteins (such drugs are known as "substrates" of these proteins). Check with your healthcare provider before taking ponatinib with any of these medications.
 
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