Cancer Channel
Topics
Medications
Quicklinks
Related Channels

Pomalyst Drug Interactions

Pomalyst Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Pomalyst is combined with any of the drugs listed above.
 
Biologic and Immunologic Medications
Taking Pomalyst with certain medications that suppress the immune system may increase your risk for side effects, including low blood cell counts and potentially serious infections. Talk to your healthcare provider before taking these medicines together.
 
Cigarette Smoking
Smoking cigarettes causes your body to break down Pomalyst faster than normal, which could make Pomalyst less effective. If you currently smoke, talk to your healthcare provider about ways to quit. 
 
Clozapine
Taking clozapine with Pomalyst may increase the risk of dangerously low white blood cells, which would increase your risk for infections. Talk to your healthcare provider before taking these medicines together. However, do not stop taking clozapine without first speaking with your healthcare provider.
 
Strong CYP 1A2 Inhibitor Medications
The liver breaks down Pomalyst using enzymes known as CYP 1A2 enzymes, and medications known as CYP 1A2 inhibitors can decrease the activity of these enzymes. Thus, combining Pomalyst with one of these drugs may increase the level of Pomalyst in your body, increasing your risk for side effects. The manufacturer of Pomalyst recommends it not be used with a strong CYP 1A2 inhibitor. 
 
Strong CYP 3A4 Inducer Medications
The liver breaks down Pomalyst using enzymes known as CYP 3A4 enzymes, and medications known as CYP 3A4 inducers can increase the activity of these enzymes. Thus, combining Pomalyst with one of these drugs may decrease the level of Pomalyst in your body, potentially making it less effective. The manufacturer of Pomalyst recommends it not be used with a strong CYP 3A4 inducer. 
 
Strong CYP 3A4 Inhibitor Medications
The liver breaks down Pomalyst using enzymes known as CYP 3A4 enzymes, and medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. Thus, combining Pomalyst with one of these drugs may increase the level of Pomalyst in your body, increasing your risk for side effects. The manufacturer of Pomalyst recommends it not be used with a strong CYP 3A4 inhibitor. 
 
Echinacea
Echinacea may decrease the effectiveness of Pomalyst. Check with your healthcare provider before taking echinacea during Pomalyst treatment.
 
Live Vaccinations
Live vaccines are vaccines that contain live viruses or bacteria. If you receive a live vaccine while taking Pomalyst, you could become infected with the virus or bacteria from the vaccine. Also, live vaccines may be less effective in people taking Pomalyst. Talk to your healthcare provider before receiving a vaccination during Pomalyst treatment.
 
Medications That Cause Drowsiness
Pomalyst can cause dizziness and confusion. Medicines that make you drowsy can also cause you to feel dizzy and confused, which could add to the effects of Pomalyst. In general, Pomalyst should be used cautiously with any medicine that causes drowsiness, dizziness, or confusion. Talk to your healthcare provider before taking these medicines together.  
 
P-glycoprotein (Pgp) Inducers
P-glycoprotein is a protein found in the body. One of its roles is to help remove substances, such as medications, out of the tissues in the body so they can be removed through the urine or feces. Pgp helps remove Pomalyst from the body. Certain other medications known as Pgp inducers increase the activity of Pgp.
 
Taking Pomalyst with one of these drugs may cause Pomalyst to be removed from the body too quickly, potentially making it less effective. The manufacturer of Pomalyst recommends these medicines not be used together.
 
P-glycoprotein (Pgp) Inhibitors
P-glycoprotein is a protein found in the body. One of its roles is to help remove substances, such as medications, out of the tissues so they can be excreted through the urine or feces. Pgp helps remove Pomalyst from the body. Certain other medications known as Pgp inhibitors decrease the activity of Pgp.
 
Taking Pomalyst with one of these drugs may cause Pomalyst to be removed more slowly than normal, potentially increasing the amount of Pomalyst in your body and increasing your risk for serious side effects. The manufacturer of Pomalyst recommends these medicines not be used together.
 
The Zen of Cancer Caregiving - Recharge Your Batteries!

Pomalyst Chemotherapy Information

Terms of Use
Advertise with Us
Contact Us
About eMedTV
Privacy Policy
Copyright © 2006-2014 Clinaero, Inc.
eMedTV serves only as an informational resource. This site does not dispense medical advice or advice of any kind. Site users seeking medical advice about their specific situation should consult with their own physician. Click Terms of Use for more information.