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Important Information for Your Healthcare Provider

You should talk with your healthcare provider prior to receiving this medication if you have:
Also, let your healthcare provider know if you are:
Make sure to tell your healthcare provider about any other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
(Click Precautions and Warnings With Pertuzumab to learn more, including information on who should not use the drug.)

How Does It Work?

Pertuzumab is part of a group of medications called monoclonal antibodies. Monoclonal antibodies are used to treat a wide variety of conditions, including cancer.
Pertuzumab is a special type of monoclonal antibody that is designed to bind to HER2, a protein on the outside of certain cancer cells. When pertuzumab binds to HER2 receptor proteins, it has several effects. It may interfere with the cancer cells' ability to grow and multiply. By binding to the HER2 receptor, the drug may also serve as a signal to the immune system, which can help destroy the cancer cells.
Pertuzumab is not a form of chemotherapy, at least in the traditional sense of the word. It is a biologic therapy, also known as biological therapy (see Biological Therapy for Breast Cancer). It is less "toxic" than chemotherapy, as it specifically targets the HER2 receptors. Because it is only used to treat cancers that have a high concentration of HER2 receptors, it targets the tumors, having less of an effect on healthy, noncancerous cells.
Before the medication can be prescribed to a particular person, certain tests must be performed to make sure that the tumor "overexpresses" HER2. When a cell makes a certain receptor or protein, it is said to "express" that receptor or protein. Tumor cells that overexpress HER2 have a high concentration of the HER2 receptor. Not all cancers overexpress HER2, and not all people with breast cancer will benefit from pertuzumab.
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Pertuzumab Drug Information

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