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Pertuzumab Dosage

Dosing Regimens for Pertuzumab

For treating metastatic breast cancer, pertuzumab may be continued indefinitely, usually until either it stops working or side effects become a problem. When using the drug for neoadjuvant treatment (before surgery to shrink the tumor size) in people with early, inflammatory, or locally advanced breast cancer, one of the following regimens is recommended:
  • Four cycles of pertuzumab plus docetaxel and trastuzumab before surgery, followed by three cycles of fluorouracil, epirubicin, and cyclophosphamide (FEC) after surgery
  • Three cycles of FEC, followed by three cycles of pertuzumab plus docetaxel and trastuzumab, all before surgery
  • Six cycles of pertuzumab plus docetaxel, trastuzumab, and carboplatin, all before surgery.
For all three regimens, trastuzumab should be continued after surgery to complete one year of treatment.

General Information on Receiving Pertuzumab

Some considerations to keep in mind during treatment with pertuzumab include the following:
  • Sometimes, people develop reactions (known as "infusion reactions") while pertuzumab is being administered by IV. In some cases, slowing the IV drip will help. In other cases, the IV may need to be stopped and other medications may need to be given in order to treat the reactions. These infusion reactions often include but are not limited to:
  • Most people receive their infusion at their healthcare provider's office, a hospital, or at an "infusion center."
  • For the medication to work properly, it must be used as prescribed. Pertuzumab will not work as well if you stop using it before your healthcare provider recommends.
  • If you are unsure about anything related to your pertuzumab dosing, please talk to your healthcare provider or pharmacist.
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