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Drug Interactions With Pertuzumab

If you are receiving pertuzumab, your doctor will need to know if you are taking any type of anthracycline medication, as these drugs can cause interactions with pertuzumab. Combining these medications can increase your risk for heart problems like congestive heart failure. In addition to telling your doctor about anthracycline drugs, be sure to give him or her a list of any other products you are taking.

An Overview of Pertuzumab Interactions

Pertuzumab (Perjeta™) can potentially react with a few other products. Some of the drugs that can lead to interactions with pertuzumab include but are not limited to:
  • Anthracyclines, such as:

More Information on Drug Interactions With Pertuzumab

People who are taking an anthracycline medication or those who have ever taken an anthracycline in the past may have a higher risk for heart problems like congestive heart failure with pertuzumab. The benefits of pertuzumab must be weighed against the increased risks in these situations.
Would pertuzumab interact with other medications besides anthracyclines? It does not appear that this possibility has been explored thoroughly. The prescribing information simply states that pertuzumab does not interact with docetaxel (Taxotere®) or trastuzumab (Herceptin®), the two medications that are usually combined with pertuzumab. No other interactions are specifically mentioned. It is possible that interactions may be discovered in the future.
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Pertuzumab Drug Information

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