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Drug Interactions With Pentostatin

More Detail on Drug Interactions With Pentostatin

The following sections explain in detail the potentially negative interactions that can occur when pentostatin is combined with any of the drugs listed above.
 
Amphotericin B
Using pentostatin with amphotericin B could increase your risk for amphotericin B side effects, including kidney damage, low blood pressure (hypotension), and lung problems. Your healthcare provider may monitor you more closely for these problems if you use these medicines together.
 
Carmustine
There have been rare reports of serious problems, including fluid in the lungs, heart arrhythmias, low blood pressure, and death, occurring in people treated with pentostatin in combination with carmustine, etoposide, and high doses of cyclophosphamide prior to a bone marrow transplant. The exact cause of these problems is unknown, but they are thought to be related to a possible interaction between cyclophosphamide and pentostatin.
 
Certain Immunosuppressant Medications
Combining pentostatin with other medicines that suppress the immune system could increase your risk for potentially serious side effects, including low blood cell counts, which may cause anemia, infection, and bleeding problems. Pentostatin should not be used in combination with certain immunosuppressants, while other combinations will require close monitoring.
 
Clozapine
Taking clozapine and pentostatin together may increase the risk for dangerously low white blood cells and potentially life-threatening infections. Talk to your healthcare provider before combining these drugs. However, do not stop taking clozapine unless your healthcare provider specifically tells you to do so.
 
Cyclophosphamide
There have been rare reports of serious problems, including fluid in the lungs, heart arrhythmias, low blood pressure, and death, occurring in people treated with pentostatin in combination with carmustine, etoposide, and high doses of cyclophosphamide prior to a bone marrow transplant. The exact cause of these problems is unknown, but may be related to a possible interaction between cyclophosphamide and pentostatin.
 
Echinacea
Echinacea may decrease the effectiveness of pentostatin. Do not take these products together without your healthcare provider's approval.
 
Etoposide
There have been rare reports of serious problems, including fluid in the lungs, heart arrhythmias, low blood pressure, and death, occurring in people treated with pentostatin in combination with carmustine, etoposide, and high doses of cyclophosphamide prior to a bone marrow transplant. The exact cause of these problems is unknown, but may be related to a possible interaction between cyclophosphamide and pentostatin.
 
Fludarabine
Combining pentostatin with fludarabine may increase the risk for life-threatening lung damage. These medicines should not be taken together.
 
Live Vaccinations
Live vaccines contain live viruses or bacteria. If you receive a live vaccine during pentostatin treatment, you could become infected with the virus or bacteria used to make the vaccine. Also, live vaccines may be less effective in people receiving pentostatin. You should not receive a live vaccine during chemotherapy treatment.
 
Nelarabine
Pentostatin may decrease the effectiveness of nelarabine. These medicines should not be used together.
 
Pegademase Bovine
Pegademase bovine and pentostatin may both be less effective if used together. It is generally recommended that these medicines not be used in combination. If they must be used together, close monitoring is recommended to ensure an adequate response to each medicine is being achieved.
 
Roflumilast
Combining roflumilast with pentostatin could increase your risk for developing an infection. Talk to your healthcare provider about this potential interaction before using these medicines together.
 
Sipuleucel-T
Pentostatin may decrease the effectiveness of sipuleucel-T. Talk to your healthcare provider about this potential interaction before using these medicines together. If you must combine these drugs, your healthcare provider may need to monitor you more closely to make sure you are adequately responding to sipuleucel-T.
 
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Pentostatin Drug Information

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