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What Is Pazopanib Used For?

Using Pazopanib for the Treatment of Advanced Soft Tissue Sarcoma

Soft tissue sarcoma is a rare type of cancer that begins in the soft tissues of the body. The soft tissues of the body are tissues that connect, support, and surround other body structures. This includes tissues such as the muscle, fat, nerves, lining of the joints, and blood vessels. Soft tissue sarcoma can occur anywhere in the body, but are most commonly found in the arms, legs, and abdomen (stomach).
Like with other cancers, healthcare providers will use staging to determine if the cancer has spread past the soft tissue to other areas of the body. Soft tissue sarcoma is considered advanced when the cancer cells have spread to other areas of the body. At this stage, the disease is generally considered incurable.
There several different types of soft tissue sarcoma, depending on the soft tissue affected. Pazopanib is approved to treat many types of soft tissue sarcoma in people who have received prior chemotherapy. However, the medication was not adequately studied in people with adipocytic soft tissue sarcoma or people with gastrointestinal stromal tumors (cancer of the gastrointestinal or GI tract) and is therefore not approved for treating these subtypes of soft tissue sarcoma.

How Does This Medicine Work?

Pazopanib works by blocking an enzyme in the body known as tyrosine kinase. This enzyme tells cancer cells to grow and divide. By blocking tyrosine kinase, pazopanib may slow down the growth of cancer cells. However, like other kidney cancer medications, it does not cure kidney cancer.

Can Children Use Pazopanib?

Pazopanib is not approved for use in children, and has not been adequately studied in this age group. Talk to your child's healthcare provider about the risks and benefits of using this medicine in children. Studies in young rats suggest that the medication could be quite dangerous in children, particularly young children. Giving pazopanib to young rats (equivalent to under two years old in humans) resulted in toxicity to the lungs, heart, liver, and kidneys, as well as other problems, including death. 
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