Precautions and Warnings With Pazopanib

Before you start taking pazopanib, talk to your healthcare provider about your medical history, particularly if you have a history of a heart attack, stroke, or any bleeding in your stomach. Other precautions for safely using pazopanib include warnings of potential drug interactions and allergic reactions. This medicine can increase your risk for other problems, such as liver problems, heart rhythm problems, and hypothyroidism.

Pazopanib Drug Information

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking

pazopanib (Votrient^®) if you have:

Liver disease, such as hepatitis, cirrhosis, or liver failure
High blood pressure (hypertension)
An irregular heartbeat or a heart condition known as QT prolongation
Heart disease
A history of heart attack or chest pain
A history of stroke or transient ischemic attack (TIA or mini-stroke)
Had bleeding in your stomach, intestines, or brain, or you have coughed up blood in the past six months
An underactive thyroid (hypothyroidism)
Had surgery in the past seven days or have an upcoming surgery
A tear in your stomach or intestines (a perforation) or an abnormal connection between two parts of your gastrointestinal tract (a fistula)
Been told you have abnormal amounts of protein in your urine
Any allergies, including to foods, dyes, or preservatives.

Also, let your healthcare provider know if you are:

Pregnant or thinking of becoming pregnant
Breastfeeding.

You should also tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

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