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Pazopanib Side Effects

Common Side Effects

Pazopanib has been studied extensively in clinical trials. In these studies, the side effects that occurred in a group of people taking the drug were carefully documented and compared to those that occurred in a similar group of people taking a placebo (a "sugar pill" that does not contain any active ingredients). As a result, it was possible to see what side effects occurred, how often they appeared, and how they compared to the placebo.
 
In these studies, common pazopanib side effects included:
 
  • Fatigue -- in up to 65 percent of people
  • Diarrhea -- up to 59 percent
  • Nausea -- up to 56 percent
  • Weight loss -- up to 48 percent
  • High blood pressure (hypertension) -- up to 42 percent
  • Decreased appetite -- up to 40 percent
  • Hair color changes (lightening of the hair) -- up to 39 percent
  • Vomiting -- up to 33 percent
  • Tumor pain -- up to 29 percent
  • Changes in taste -- up to 28 percent
  • Headache -- up to 23 percent
  • Muscle or bone pain -- up to 23 percent
  • Abdominal (stomach) pain -- up to 23 percent.
 
Other common reactions, occurring in 1 to 20 percent of people, included:
 
  
  • Shortness of breath
  • Rash
  • Cough
  • Swelling of the arms, hands, legs, ankles, or feet
  • Mouth sores or swelling
  • Loss of strength or energy
  • Hair loss
  • Dizziness
  • Abnormal amounts of protein in the urine
  • Chest pain
  • Heartburn or indigestion
  • Swelling of the face
  • Redness, tenderness, and peeling of the palms of the hands and soles of the feet
  • Lightening of the skin
  • Insomnia
  • An underactive thyroid (hypothyroidism)
  • A slow heart rate
  • Difficulty speaking
  • Nosebleeds
  • Dry skin
  • Chills
  • Blurred vision
  • Changes in finger or toenails.
 
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