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Dosing Information for Pazopanib

The dose of pazopanib your healthcare provider recommends will vary, depending on a number of factors, including:
  • Your liver function
  • Other medications you may be taking.
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.
(Click Pazopanib Dosage for more information.)

Drug Interactions

Pazopanib may react with a number of other medicines (see Drug Interactions With Pazopanib).

What If I Take an Overdose?

It is not exactly known what to expect from an overdose with pazopanib. Seek immediate medical attention if you or someone else may have taken too much of this or any other medication.
(Click Votrient Overdose for more information.)

What If I Miss a Dose of Pazopanib?

If you miss a dose of pazopanib, take it as soon as you remember, as long as it is at least 12 hours until your next scheduled dose. If your next dose is less than 12 hours away, simply skip your missed dose and continue with your regular schedule.

How Does This Drug Work?

Pazopanib works by blocking an enzyme in the body known as tyrosine kinase. This enzyme tells cancer cells to grow and divide. By blocking tyrosine kinase, pazopanib may slow down the growth of cancer cells.

Clinical Effects

In clinical studies, pazopanib improved "progression-free survival" (PFS), which is the period of time the cancer does not get worse. In one study, people with advanced kidney cancer who took pazopanib had an average of 9.2 months of PFS, compared with 4.2 months in people taking a placebo (a "sugar pill" that does not contain any active ingredients). In another study, people with soft tissue cancer experienced an average of 4.6 months of PFS, while people given a placebo had 1.6 months of PFS.
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Pazopanib Drug Information

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