Drug Interactions With Pazopanib

Certain vaccinations, echinacea, and even grapefruit juice may cause reactions with pazopanib. Drug interactions with this medication can lead to serious complications, such as infections, blood cell problems, and kidney problems. Some interactions can also alter the effectiveness of your medications. To reduce your risk, let your healthcare provider know about any other medications, vitamins, or supplements you are taking before beginning treatment with pazopanib.

• CYP 3A4 inducer medications, such as:

• • Aminoglutethimide (Cytadren^®)
  • Bosentan (Tracleer^®)
  • Carbamazepine (Carbatrol^®, Epitol^®, Equetro^®, Tegretol^®)
  • Dexamethasone (Decadron^®, Dexpak^®, Maxidex^®)
  • Efavirenz (Sustiva^®)
  • Efavirenz, emtricitabine, and tenofovir (Atripla^®)
  • Etravirine (Intelence™)
  • Fosphenytoin (Cerebyx^®)
  • Nafcillin
  • Nevirapine (Viramune^®)
  • Oxcarbazepine (Trileptal^®)
  • Pentobarbital (Nembutal^®)
  • Phenobarbital (Luminal^®)
  • Phenytoin (Dilantin^®, Phenytek^®)
  • Primidone (Mysoline^®)
  • Rifabutin (Mycobutin^®)
  • Rifampin (Rifadin^®)
  • Rifapentine (Priftin^®)
  • St. John's wort

• CYP 3A4 inhibitor medications, such as:

• • Amprenavir (Agenerase^®)
  • Atazanavir (Reyataz^®)
  • Clarithromycin (Biaxin^®)
  • Conivaptan (Vaprisol^®)
  • Crizotinib (Xalkori^®)
  • Darunavir (Prezista^®)
  • Delavirdine (Rescriptor^®)
  • Erythromycin
  • Fluconazole (Diflucan^®)
  • Fosamprenavir (Lexiva^®)
  • Imatinib (Gleevec^®)
  • Indinavir (Crixivan^®)
  • Isoniazid
  • Itraconazole (Sporanox^®)
  • Ketoconazole (Nizoral^®)
  • Lopinavir and ritonavir (Kaletra^®)
  • Miconazole
  • Nefazodone (Serzone^®)
  • Nelfinavir (Viracept^®)
  • Nicardipine (Cardene^®)
  • Posaconazole (Noxafil^®)
  • Quinidine
  • Ritonavir (Norvir^®)
  • Saquinavir (Fortovase^®, Invirase^®)
  • Telaprevir (INCIVEK™)
  • Telithromycin (Ketek^®)
  • Voriconazole (VFEND^®)

• Denosumab (Prolia^®)
• Echinacea
• Grapefruit juice
• Leflunomide (Arava^®)
• "Live" vaccinations, such as:

• • Chickenpox vaccine (varicella vaccine)
  • FluMist^® (the nasal vaccine for influenza; the injected vaccine is not live)
  • MMR vaccine (measles, mumps, rubella vaccine)
  • Polio vaccine
  • Rotavirus vaccine
  • Smallpox vaccine
  • Yellow fever vaccine
  • BCG vaccine (used in some countries for tuberculosis)

• Medications that cause a certain change in the heart rhythm known as QT prolongation (see QT-Prolonging Medications for a list of such medications)
• Natalizumab (Tysabri^®)
• Other chemotherapy medicines 
• P-glycoprotein inducers, such as:

• • Carbamazepine (Carbatrol^®, Epitol^®, Equetro^®, Tegretol^®)
  • Dexamethasone (Decadron^®)
  • Doxorubicin (Adriamycin^®, Doxil^®)
  • Nefazodone (Serzone^®)
  • Prazosin (Minipress^®)
  • Rifampin (Rifadin^®)
  • St. John's wort
  • Tipranavir (Aptivus^®)
  • Trazodone (Desyrel^®) and trazodone ER (Oleptro™)
  • Vinblastine

• P-glycoprotein inhibitors, such as:

• • Amiodarone (Cordarone^®, Pacerone^®)
  • Atorvastatin (Lipitor^®) or combination medications that contain atorvastatin (Caduet^®, Liptruzet™)
  • Carvedilol (Coreg^®, Coreg CR^®)
  • Clarithromycin (Biaxin^®)
  • Cyclosporine (Gengraf^®, Neoral^®, Sandimmune^®)
  • Darunavir (Prezista^®)
  • Dipyridamole (Persantine^®, also found in Aggrenox^®)
  • Dronedarone (Multaq^®)
  • Erythromycin
  • Grapefruit juice
  • Itraconazole (Sporanox^®)
  • Ketoconazole (Nizoral^®)
  • Lapatinib (Tykerb^®)
  • Lopinavir and ritonavir (Kaletra^®)
  • Mefloquine (Lariam^®)
  • Nelfinavir (Viracept^®)
  • Nicardipine (Cardene^®)
  • Nilotinib (Tasigna^®)
  • Progesterone
  • Propranolol (Inderal^®, Inderal LA^®, InnoPran XL^®, also found in Inderide^®)
  • Quinidine
  • Ranolazine (Ranexa^®)
  • Reserpine
  • Ritonavir (Norvir^®, also found in Kaletra^®)
  • Saquinavir (Invirase^®)
  • Sunitinib (Sutent^®)
  • Tacrolimus (Prograf^®, Protopic^®)
  • Tamoxifen (Nolvadex^®)
  • Telaprevir (INCIVEK™)
  • Verapamil (Calan^®, Calan SR^®, Covera-HS^®, Isoptin SR^®, Verelan^®, Verelan PM^®)

• Pimecrolimus (Elidel^®)
• Sipuleucel-T (PROVENGE^®)
• Statin medications, such as:
  • Atorvastatin (Lipitor^®) or combination medications that contain atorvastatin (Caduet^®, Liptruzet™)
  • Fluvastatin (Lescol^®, Lescol^® XL)
  • Lovastatin (Altoprev^®, Mevacor^®) or combination medications that contain lovastatin (Advicor^®)
  • Pravastatin (Pravachol^®)
  • Rosuvastatin (Crestor^®)
  • Simvastatin (Zocor^®) or combination medications that contain simvastatin (Vytorin^® or Simcor^®)

• Tacrolimus ointment (Protopic^®)
• Trastuzumab (Herceptin^®).