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Drug Interactions With Pazopanib

P-glycoprotein (Pgp) Inhibitors
P-glycoprotein is a natural protein that helps remove substances, such as medications, from the tissues in the body so they can be excreted through the urine or feces. Pgp helps remove pazopanib from the body. Certain other medications known as Pgp inhibitors decrease the activity of Pgp.
 
When taken with a Pgp inhibitor, pazopanib may be removed from the body more slowly, potentially increasing pazopanib blood levels and the risk for side effects. Your healthcare provider may choose to monitor you more closely if you take pazopanib with a Pgp inhibitor, and lower your dose if needed.
 
Pimecrolimus
In general, people taking pazopanib should not use pimecrolimus because of an increased risk for infection, lymphoma (cancer of the lymph nodes), and skin cancer. Talk to your healthcare provider before taking these medicines together.
 
Sipuleucel-T
Taking pazopanib with sipuleucel-T can make sipuleucel-T less effective. Talk to your healthcare provider before taking these medicines together.
 
Statin Medications
People who take pazopanib with simvastatin may have a higher risk for developing increased liver enzymes, which could be a sign of liver damage. It is unknown if this interaction applies to other statin medicines. However, all statin medicines (as well as pazopanib) have the potential to cause liver damage. If you take these medicines together and have an increase in your liver enzymes, your healthcare provider may choose to increase your pazopanib dosage, or stop your statin medicine.
  
Tacrolimus Ointment
Combining pazopanib with tacrolimus ointment may increase your risk for potentially serious side effects, including kidney problems, diabetes, and slow wound healing. You should talk to your healthcare provider before taking these medicines together.
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Pazopanib Drug Information

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