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Drug Interactions With Pazopanib

Leflunomide
Combining leflunomide with pazopanib may increase your risk for blood cell problems, including abnormally low red blood cells, white blood cells, and platelets. Your healthcare provider will likely monitor you for these problems if you take these medications together.
 
Live Vaccinations
Live vaccines contain live viruses or bacteria. If you receive a live vaccine while taking pazopanib, you might become infected with the virus or bacteria from the vaccine. Also, live vaccines may be less effective in people taking pazopanib. Talk to your healthcare provider before receiving a vaccination or immunization while taking this medication.
 
Other Chemotherapy Medications
Pazopanib is not approved for use in combination with other chemotherapy medicines. In clinical studies, people who took the medicine with certain other cancer medicines (pemetrexed [Alimta®] and lapatinib [Tykerb®]) had an increased risk for death and life-threatening side effects, including bleeding in the lungs, stomach, or intestines.
  
QT-Prolonging Medications
Pazopanib can cause a certain change in the heart rhythm known as QT prolongation. Taking pazopanib with other medications that may cause QT prolongation can increase your risk for this potentially life-threatening problem. Your healthcare provider may need to monitor you for this if you take pazopanib with another QT-prolonging medication.
 
Natalizumab
Combining pazopanib with natalizumab may increase your risk for developing infections, including potentially serious infections. It is generally recommended that these medications not be taken together.
 
P-glycoprotein (Pgp) Inducers
P-glycoprotein is a natural protein that helps remove substances, such as medications, from the tissues in the body so they can be excreted through the urine or feces. Pgp helps remove pazopanib from the body. Medications known as Pgp inducers increase the activity of Pgp.
 
When taken with a Pgp inducer, pazopanib may be removed from the body too quickly, potentially making it less effective. Your healthcare provider may choose to monitor you more closely if you take these medications together.
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Pazopanib Drug Information

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