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What Is Panitumumab Used For?

Adults who have colorectal cancer that has spread to other areas of the body may receive panitumumab to help slow down the progression of this cancer. This medicine works by binding to a certain protein on the surface of the cancer cells, which prevents the cells from growing. Panitumumab may also be used for unapproved ("off-label") uses, such as treating non-small cell lung cancer and kidney cancer.

An Overview of Uses for Panitumumab

Panitumumab (Vectibix®) is a prescription medication approved for the treatment of colorectal cancer, a type of cancer that occurs when cancerous cells form in the tissue of the large intestine (colon) or rectum. It is given as an intravenous (IV) infusion, which is a slow injection into a vein.
Panitumumab is reserved for use when colorectal cancer has spread beyond the colon or rectum to other parts of the body despite treatment with standard chemotherapy, such as:
Colorectal cancer that has spread is called metastatic colorectal cancer, or stage IV colorectal cancer.
This medicine is meant to be used as a single agent. It is not approved for use in combination with other chemotherapy medicines. It is also designed only for use in cancers that have a protein called the epidermal growth factor receptor (EGFR) on the surface of the cancer cells. Your healthcare provider will test your cancer for EGFR protein expression.
Panitumumab may extend the time until metastatic colorectal cancer progresses. It has not been shown to extend overall survival or improve cancer symptoms.
Panitumumab is not approved for use in people with KRAS mutation-positive metastatic colorectal cancer or in people where the KRAS status is unknown. People with tumors that have the KRAS mutation have not shown a treatment benefit with panitumumab.
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Panitumumab Drug Information

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