Cancer Channel
Related Channels


Effects of Pamidronate

Pamidronate has been studied in several studies for various conditions.
Paget's Disease
One way to assess the severity of Paget's disease is by measuring the level of alkaline phosphate in the blood. In studies, pamidronate was shown to decrease alkaline phosphate levels, which indicates that it helps to improve Paget's disease.
High Blood Calcium
One study compared pamidronate with etidronate (Didronel®), another bisphosphonate, for the treatment of high blood calcium due to cancer. Seven days after treatment, 70 percent of people who took pamidronate had normal calcium levels, compared to just 41 percent of those who took etidronate.
Bone Cancer
Pamidronate has also been studied for preventing broken bones and other bone problems in people with multiple myeloma cancers or breast cancer that had spread to the bone. These studies measured the occurrence of indicators of bone problems, such as broken bones, bone surgery, bone radiation therapy, and spinal cord compression (pressure on the spinal cord caused by spinal fractures or other problems). People who took pamidronate had fewer of these problems, compared to those who did not take pamidronate. The drug also delayed the development of these bone problems.

When and How to Take Pamidronate

General considerations for when and how to take the medication include the following:
  • Pamidronate comes in injection form. It is given through IV by your healthcare provider, usually at a hospital or clinic.
  • For high blood calcium, it is taken as a single dose, given by IV over 2 to 24 hours (although in some situations, retreatment with pamidronate may be necessary).
  • For Paget's disease, pamidronate is taken in three doses on consecutive days, given by IV over four hours for each dose.
  • For multiple myeloma, it is taken every month, given by IV over four hours.
  • For breast cancer that has spread to the bone, it is taken every three to four weeks, given by IV over two hours.
  • It is important that you get enough calcium and vitamin D while taking pamidronate (unless you are taking pamidronate for high blood calcium).
  • It does not matter if you take pamidronate on an empty or full stomach.
  • It is very important that you are well hydrated before receiving your dose in order to protect your kidneys. Make sure to drink enough fluids in the days before your pamidronate dose. In many cases, your healthcare provider may need to give you IV fluids to make sure you are hydrated enough.
7 Natural Ways to Reduce Your Cancer Pain

Pamidronate Disodium -- Drug Information

Terms of Use
Advertise with Us
Contact Us
About eMedTV
Privacy Policy
Copyright © 2006-2019 Clinaero, Inc.
eMedTV serves only as an informational resource. This site does not dispense medical advice or advice of any kind. Site users seeking medical advice about their specific situation should consult with their own physician. Click Terms of Use for more information.