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Pamidronate Dosing

Pamidronate Dosing for Preventing Bone Problems

Pamidronate is also used to prevent bone problems (such as broken bones) in people with cancer. For multiple myeloma, the recommended dose of pamidronate is 90 mg once a month, given by IV over four hours. For breast cancer that has spread to the bones, the recommended pamidronate dose is 90 mg given every three to four weeks, given by IV over four hours. Your healthcare provider should check your kidney function (using a simple blood test) before each dose to make sure pamidronate is not affecting your kidneys too much.

General Information on Dosing With Pamidronate

Considerations for people taking pamidronate include the following:
  • The medication comes in injection form. It is given through IV by your healthcare provider, usually at a hospital or clinic.
  • For high blood calcium, pamidronate is taken as a single dose, given by IV over 2 to 24 hours (although in some situations retreatment with pamidronate may be necessary).
  • For Paget's disease, pamidronate is taken in three doses on consecutive days, given by IV over four hours for each dose.
  • For multiple myeloma, pamidronate is taken every month, given by IV over four hours.
  • For breast cancer that has spread to the bone, pamidronate is taken every three to four weeks, given by IV over two hours.
  • It is important that you get enough calcium and vitamin D while taking pamidronate (unless you are taking pamidronate for high blood calcium).
  • It does not matter if you take pamidronate on an empty or full stomach.
  • It is very important that you are well hydrated before receiving your pamidronate dose in order to protect your kidneys. Make sure to drink enough fluids in the days before your pamidronate dose. In many cases, your healthcare provider may need to give you IV fluids to make sure you are hydrated enough.
  • If you are unsure about anything related to pamidronate or your pamidronate dosage, please talk with your doctor, nurse, or pharmacist. Do not stop taking the drug without first discussing it with your healthcare provider.
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