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Drug Interactions With Pamidronate

Pamidronate Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when pamidronate is combined with any of the drugs listed above.
 
Aminoglycosides
Taking pamidronate with an aminoglycoside antibiotic can increase the risk of low blood calcium (hypocalcemia) and kidney damage. Talk to your healthcare provider before taking these medications together.
 
Diuretics
Combining pamidronate with a diuretic may increase the risk of kidney damage. It is very important that you are adequately hydrated before your pamidronate dose, particularly if you are taking a diuretic. If you are not adequately hydrated, your healthcare provider may need to give you IV fluids before your pamidronate dose. Also, some diuretics (but not all) can increase the risk of low blood calcium with pamidronate. Talk with your healthcare provider before taking pamidronate with a diuretic.
 
Nonsteroidal Anti-Inflammatory Drugs (NSAIDS)
Combining an NSAID with pamidronate may increase the risk of kidney damage, particularly in people who already have kidney disease. Talk with your healthcare provider before combining pamidronate with an NSAID.
 
Thalidomide (Thalomid)
Combining thalidomide with pamidronate can increase the risk of kidney damage, especially in people with multiple myeloma (a certain type of cancer). Talk to your healthcare provider before using these medications together.
 
Vancomycin (Vancocin)
Taking pamidronate with vancomycin can increase your risk of kidney damage. Talk with your healthcare provider before taking these medications together, particularly if you already have kidney disease.
 
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