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Oxymorphone ER Side Effects

Common Side Effects

Oxymorphone ER has been studied extensively in clinical trials. Some of these studies compared oxymorphone ER to a similar product that did not contain any active ingredients (a placebo).
In these studies, the most common oxymorphone ER side effects included:
  • Nausea -- in up to 33 percent of people
  • Constipation (see Opana ER and Constipation) -- up to 28 percent
  • Drowsiness -- up to 19 percent
  • Dizziness -- up to 18 percent
  • Vomiting -- up to 16 percent
  • Itching -- up to 15 percent
  • Headache -- up to 12 percent.
Opioids like oxymorphone ER can cause a release of histamine, resulting in itching unrelated to any allergy. If you develop itching but do not have any other allergy symptoms, it is unlikely that you are allergic to oxymorphone ER. However, tell your healthcare provider if this side effect becomes bothersome, as there are medications available to help relieve the itching.
Other common reactions, occurring in 3 percent to 6 percent of people, included:
  • Dry mouth
  • Insomnia
  • Fatigue
  • Decreased appetite
  • Abdominal (stomach) pain.

Final Thoughts

You may experience some or none of the side effects listed in this article. Unfortunately, there is no way for your healthcare provider to know beforehand if you will have problems with a medicine that you have never tried.
Therefore, make sure to let your healthcare provider know if you develop any side effects while taking oxymorphone ER. Also, let your healthcare provider know if you develop something that "just does not seem right." While it may not be related to the medication, your healthcare provider will be able to diagnose and treat the problem.
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