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Onsolis Drug Interactions

CYP 3A4 Inhibitor Medications
The body breaks down Onsolis using enzymes in the liver known as CYP 3A4 enzymes. Medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. Combining Onsolis with one of these drugs may increase the level of Onsolis in your body, increasing your risk for serious side effects, including drowsiness, confusion, and breathing problems. Your healthcare provider may monitor you more closely for side effects if you use these medicines together.
 
Desmopressin
Onsolis can increase the risk for desmopressin side effects. Do not use Onsolis with desmopressin without first talking to your healthcare provider about this potential drug interaction.
 
Grapefruit Juice
Grapefruit juice may increase the amount of Onsolis in your blood, potentially increasing your risk for serious side effects, such as drowsiness, confusion, and breathing problems. Talk to your healthcare provider before eating grapefruit or drinking grapefruit juice while you are using Onsolis.
 
Medications That Cause Drowsiness
Onsolis causes significant drowsiness. Taking other medications that cause drowsiness while using Onsolis may lead to serious side effects, including extreme sedation, confusion, and breathing problems. Check with your healthcare provider before using Onsolis with other drugs that may cause drowsiness.
 
Monoamine Oxidase Inhibitors (MAOIs)
Combining Onsolis with an MAOI may cause a potentially dangerous reaction known as serotonin syndrome. It may also lead to low blood pressure. Do not use Onsolis if you have taken an MAOI within the past 14 days.
 
Octreotide
Combining octreotide with Onsolis may increase the pain-relieving effects of Onsolis. Your healthcare provider may monitor your pain response more closely if you use these medications together. You might need a lower Onsolis dose.
Alternative Therapies for Pain Management

Onsolis Drug Information

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