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Precautions and Warnings With Omacetaxine

If you have diabetes, an infection, or other medical issue, ask your healthcare provider if omacetaxine can increase your risk for certain complications. In some people, this drug may cause bone marrow depression, low blood cell counts, or other potentially dangerous problems. There are also important precautions for women who are pregnant or nursing, along with warnings for potential drug interactions.

What Should I Tell My Healthcare Provider?

Talk with your healthcare provider prior to receiving omacetaxine mepesuccinate (Synribo™) if you have:
  • An infection of any kind
  • Low white blood cell counts
  • Diabetes or high blood sugar (blood glucose) levels
  • Any allergies, including to foods, dyes, or preservatives. 
Also, let your healthcare provider know if you are:
  • Breastfeeding
  • Pregnant or thinking of becoming pregnant.
You should also tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Omacetaxine Precautions and Warnings

Some warnings and precautions to be aware of prior to using this medication include the following:
  • Omacetaxine can cause bone marrow suppression (when the bone marrow is unable to produce adequate amounts of blood cells), which can lead to abnormally low white blood cells, red blood cells, and platelets. This can increase your risk for potentially serious infections, anemia, and bleeding problems.
  • Your healthcare provider will regularly monitor your blood counts using a simple blood test throughout treatment. Make sure to keep all of your healthcare appointments. Also, let your healthcare provider know if you experience signs of bone marrow suppression; for example:
    • Signs of infection, such as:
      • Fever
      • Chills
      • Body aches
      • Sore throat
      • Painful urination
    • Signs of anemia, such as:
      • Fatigue
      • Pale skin
      • Shortness of breath
      • Dizziness
    • Signs of bleeding, such as:
      • Unusual bleeding or bruising
      • Blood in the stool or urine
      • Coughing or spitting up blood
      • Confusion, slurred speech, or changes in vision.
  • This medication has been reported to cause hyperglycemia (high blood sugar). You will need frequent monitoring of blood glucose levels, especially if you have diabetes. People with diabetes should not begin treatment with omacetaxine unless their blood glucose levels are under control.
  • This medication can make you extremely tired. Do not drive, operate heavy machinery, or perform any other activity that requires alertness until you know how it affects you.
  • It is unknown if omacetaxine passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to using the drug (see Synribo and Breastfeeding).
  • Omacetaxine is a pregnancy Category D medication, which means it may harm an unborn baby if used during pregnancy (see Synribo and Pregnancy).
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Omacetaxine Mepesuccinate Information

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