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What Is Ofatumumab Used For?

How Does It Work?

An antibody (also known as an immunoglobulin) is a protein made by the immune system. Antibodies attach to antigens, which are proteins found on foreign substances that enter the body. Once attached, the antibody marks the substance for destruction by the immune system.
Ofatumumab is an antibody that is made in a laboratory (as opposed to a naturally occurring antibody). It works by binding to CD20, a specific antigen found on the surface of healthy cells and leukemia B cells (a type of white blood cell). By binding to the CD20 antigen on leukemia cells, ofatumumab signals the immune system to attack and destroy the leukemia cells.

Can Children Use Ofatumumab?

Ofatumumab is not approved for use in children (usually defined as individuals younger than 18 years of age), as it has not been adequately studied in this age group. Talk to your child's healthcare provider about the risks and benefits of using this medication in children.

Is It Safe for Older Adults?

Ofatumumab has not been adequately studied in older adults, so it is unknown whether older adults will respond differently to this medication than younger age groups. Although ofatumumab can be used in older adults, it should be used cautiously and with close monitoring until more information is known about its effects in older adults.

Are There Off-Label Reasons to Use Ofatumumab?

On occasion, your healthcare provider may recommend this medication for treating something other than chronic lymphocytic leukemia. This is called an "off-label" use. Ofatumumab may sometimes be used off-label to treat rheumatoid arthritis.
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