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Ofatumumab Side Effects

Common Side Effects

Ofatumumab has been studied extensively in clinical trials. In these studies, the side effects that occurred in a group of people receiving ofatumumab were carefully documented. As a result, it was possible to see what side effects occurred and how often they appeared.
In clinical studies, the most common ofatumumab side effects included:
  • Infections, including bacterial, viral, and fungal infections -- in up to 70 percent of people
  • Infusion reactions (a reaction that happens while receiving or soon after your dose; see the section above for symptoms of this potentially dangerous reaction) -- up to 67 percent
  • Low white blood cell counts -- up to 67 percent 
  • Fever -- up to 20 percent
  • Coughing -- up to 18 percent
  • Diarrhea -- up to 18 percent
  • Low red blood cell counts (anemia) -- up to 16 percent
  • Fatigue -- up to 15 percent
  • Shortness of breath -- up to 14 percent
  • A rash -- up to 14 percent.
Other common side effects, occurring in 5 percent to 11 percent of people, included:
  • Nausea
  • General weakness
  • Swelling in the arms, hands, legs, ankles, or feet
  • Joint pain
  • Upper abdominal pain
  • Chills
  • Hives
  • Back pain
  • Insomnia
  • Headache
  • High or low blood pressure (hypertension or hypotension)
  • Fast heart rate (tachycardia)
  • Increased sweating
  • Muscle spasms.
Some of the most common infections that occurred in ofatumumab clinical trials included:
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