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Ofatumumab and CLL

If you have been diagnosed with chronic lymphocytic leukemia (CLL), ofatumumab (Arzerra®) may be prescribed as part of your treatment. This drug is reserved for people who have not adequately responded to certain other chemotherapy treatment. Although the medicine has not been shown to decrease symptoms or prolong survival, one clinical study showed that some people who had failed other treatments had at least a partial response to ofatumumab.
CLL is a slow-growing leukemia affecting lymphocytes, a type of blood cell. This type of leukemia is more likely to develop in people who are 55 years old and older. It rarely occurs in children. Ofatumumab works by binding to a certain protein on the surface of healthy cells and leukemia B cells. As a result, ofatumumab signals the immune system to attack and destroy the leukemia cells.
(Click What Is Ofatumumab Used For? for a closer look at how ofatumumab can help treat CLL. This article also lists other possible uses and talks about whether the medicine is safe for use in older adults and children.)
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