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Nilutamide Side Effects

Common Side Effects

Nilutamide has been studied extensively in clinical studies. In these studies, one group of people received the real medication, while another group was given a placebo (a "sugar pill" that does not contain any active ingredients). As a result, it was possible to see what nilutamide side effects occurred, how often they appeared, and how they compared to the placebo.
 
In these studies, the most common side effects of nilutamide included:
 
  • Hot flushes -- in up to 66.5 percent of men
  • Problems seeing in the dark -- up to 56.9 percent
  • General body pain -- up to 26.8 percent
  • Nausea -- up to 23.9 percent
  • Constipation -- up to 19.6 percent
  • Weakness or fatigue -- up to 19.1 percent
  • Testicular atrophy (shrinking of the testicles) -- up to 16.3 percent
  • Insomnia -- up to 16.3 percent
  • Headaches -- up to 13.9 percent
  • Increase in liver enzymes -- up to 12.9 percent
  • Swelling in the arms, hands, legs, ankles, or feet -- up to 12.4 percent
  • Back pain -- up to 11.5 percent
  • Decreased libido (sex drive) -- up to 11.0 percent
  • Impotence (erectile dysfunction or ED) -- up to 11.0 percent
  • Decreased appetite -- up to 11.0 percent.
 
Other common side effects, occurring in 5.3 to 10.5 percent of men, included:
 
  • Breast enlargement
  • Shortness of breath
  • Dizziness
  • Abdominal (stomach) pain
  • Increased blood pressure (hypertension)
  • Urinary tract infections (UTIs)
  • Blood in the urine
  • Vision problems, including abnormal color vision and difficulty adapting to light
  • Upper respiratory tract infections
  • Depression
  • Chest pain
  • Flu-like symptoms
  • Decrease in red blood cells (anemia)
  • Needing to get up in the middle of the night to urinate
  • Sweating
  • Bone pain
  • Indigestion or heartburn
  • Fever
  • Vomiting
  • Dry skin
  • Loss of body hair
  • Rash
  • Decreased sensation of touch.
 
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