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What If I Forget a Dose of Nilutamide?

If you forget to take a dose of nilutamide, simply take it as soon as you remember, unless it is almost time for your next dose. In that case, skip your missed dose and take your normal dose the following day, at the usual time. Do not take a double dose.

How Does It Work?

Nilutamide is an androgen receptor inhibitor, or antiandrogen. Androgens are male sex hormones, such as testosterone. Prostate cancer grows in response to testosterone. Nilutamide works by blocking androgen receptors, which prevents testosterone from binding to and activating prostate cancer cells. This helps slow down the growth of prostate cancer.
Nilutamide is used after orchiectomy (surgery to remove the testicles). The testicles produce the majority of testosterone in the body, and removing them significantly reduces testosterone levels. Nilutamide blocks the effects of the remaining testosterone.

Clinical Effects

In a clinical study, nilutamide was shown to extend life and improve symptoms of bone pain in men with prostate cancer who had their testicles surgically removed. In the study, men who received nilutamide survived approximately four months longer, on average, than men who received a placebo (a "sugar pill" that does not contain any active ingredients). In addition, 54 percent of men taking nilutamide experienced improvement in their bone pain, compared to 37 percent of those taking the placebo.

When and How to Take This Medicine

Some general considerations to keep in mind during treatment with nilutamide include the following:
  • Nilutamide comes in tablet form. It is usually taken by mouth once a day.
  • Try to take your dose at the same time each day, to keep an even level of the medicine in your bloodstream.
  • Nilutamide can be taken with or without food. Try taking it with food if it upsets your stomach.
  • For the medication to work properly, it must be taken as prescribed. Do not stop taking this medicine because you feel better.
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