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What Is Nilotinib Used For?

How Does This Medicine Work?

Nilotinib works by blocking a protein in the body known as tyrosine kinase. Tyrosine kinase is responsible for telling leukemia cancer cells to grow and multiply. By blocking this protein, nilotinib slows down the progression of the disease.

Can Children Use It?

Nilotinib is not approved for use in children (usually defined as individuals younger than 18 years of age), as it has not been adequately studied in this age group. Talk to your child's healthcare provider about the risks and benefits of using this medication in children.

Is It Safe for Older Adults?

Older adults can use nilotinib. However, some older adults may be more sensitive to nilotinib side effects and may need to be monitored more closely. Also, in clinical studies, older adults with accelerated phase CML did not seem to respond as well to nilotinib treatment as younger adults.

Are There Off-Label Reasons to Use Nilotinib?

On occasion, your healthcare provider may recommend this medicine for treating something other than the approved uses. This is called an "off-label" use. Nilotinib may be used off-label in the treatment of the following conditions:
  • Other types of leukemia
  • Gastrointestinal stromal tumors (GIST)
  • CML in the blast phase
  • Systemic mast cell disease (mastocytosis, a condition characterized by too many mast cells, a type of immune system cell).
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Nilotinib Drug Information

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