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Nilotinib Dosage

For people undergoing leukemia treatment with nilotinib, dosing typically starts at 200 mg or 300 mg twice daily. It is important not to take your dose with food, as doing so can increase the levels of the medication in your blood and cause serious side effects. If you develop problems while using this drug, you may need to temporarily stop taking nilotinib until side effects resolve.

An Introduction to Your Dosage of Nilotinib

The dosage of nilotinib (Tasigna®) your healthcare provider recommends will vary, depending on a number of factors, including:
  • Whether you have been previously treated for leukemia
  • Whether you experience side effects
  • Other medical conditions you may have
  • Other medications you are taking.
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.

Nilotinib Dosing Guidelines

The standard dosage of nilotinib for people who are newly diagnosed with chronic myeloid leukemia (CML) in the chronic phase (the beginning stage) is 300 mg twice daily. The standard dosage for people with chronic or accelerated phase CML who are no longer benefiting from or cannot tolerate imatinib (Gleevec®), another leukemia medicine, is 400 mg twice daily.
People with liver disease who are newly diagnosed with CML are usually started on nilotinib 200 mg twice daily and increased to 300 mg twice daily if the medication is tolerated. People with liver disease who cannot tolerate imatinib are usually started on nilotinib 200 mg (for mild-to-moderate liver disease) or 300 mg twice daily (for severe liver disease), and increased to the standard dosage of 400 mg twice daily if tolerated.
People who experience certain side effects, such as abnormally low blood cell counts, may need to temporarily stop taking the medicine until the side effects resolve. Nilotinib may then be restarted at the same dosage or a lower dosage. In some cases, once-daily dosing may be recommended. Also, people who take certain other medications may be given lower nilotinib doses (see Drug Interactions With Nilotinib).
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Nilotinib Drug Information

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