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Drug Interactions With Nilotinib

Proton Pump Inhibitors
In general, nilotinib should not be combined with proton pump inhibitors. This is because proton pump inhibitors reduce the amount of nilotinib absorbed from the stomach into the bloodstream, which could make it less effective.
 
Silodosin
Nilotinib may increase blood levels of silodosin, possibly increasing the risk for serious side effects. In general, people taking nilotinib should not take silodosin.
 
Tacrolimus Ointment
In general, people taking nilotinib should not use tacrolimus ointment because of an increased risk for infections, skin cancer, and lymphoma (cancer of the lymph nodes). Talk to your healthcare provider before taking these medications together.
 
Topotecan
Nilotinib may increase blood levels of topotecan, possibly increasing the risk for side effects. Do not take these medicines together without your healthcare provider's approval.
 

Final Thoughts

Nilotinib has the potential to interact with numerous other medications, far too many to include in this article. Therefore, not all drug interactions with nilotinib were discussed here.
 
Make sure your healthcare provider and pharmacist are aware of all the medicines you are taking, including prescription and nonprescription medications, vitamins, and herbal supplements. Speak with your pharmacist or healthcare provider about specific nilotinib drug interactions that may apply to you.
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Nilotinib Drug Information

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