Neupogen Dosage

When used to prevent infections with bone marrow transplants or to aid in stem cell collection, the recommended Neupogen dosage is 10 mcg per kg of body weight daily. For preventing infections during chemotherapy, the recommended daily dose is 5 mcg per kg of weight. The usual Neupogen dosing for congenital neutropenia is 6 mcg per kg twice a day.

 

Neupogen Dosage: An Introduction

The dose of Neupogen® (filgrastim) that your healthcare provider recommends will vary depending on a number of factors, including:
 
  • Your weight
  • How you respond to Neupogen
  • The condition being treated
  • Other medical conditions you may have
  • Other medications you may currently be taking.
     
As always, do not adjust your Neupogen dose unless your healthcare provider specifically instructs you to do so.
 

Neupogen Dosing During Chemotherapy

The recommended starting Neupogen dose for preventing infections during chemotherapy is based on body weight -- Neupogen 5 mcg per kg each day (about 2.3 mcg per pound daily) given either by an injection under the skin or by an IV. It should be started at least 24 hours after chemotherapy and continued for up to two weeks or until your neutrophil levels increase enough. If necessary, your healthcare provider may increase your Neupogen dose for subsequent chemotherapy cycles.
 

Neupogen Dosing for Bone Marrow Transplantation

For preventing infections with bone marrow transplants, the recommend dose of Neupogen is 10 mcg per kg daily (about 4.5 mcg per pound each day) given by IV. The first dose should be given at least 24 hours after the transplantation. Your healthcare provider will adjust your dose based on your neutrophil levels and will stop the Neupogen when the neutrophil level stays high enough for three or more days.
(Neupogen Dosage Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;