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Mutamycin Warnings and Precautions

If you have stomach or pancreatic cancer and your healthcare provider recommends treatment with Mutamycin, you should understand that this drug may cause serious breathing problems, bone marrow suppression, or other potentially dangerous complications. Some of the other warnings for using Mutamycin safely include precautions for people who have certain medical issues, such as kidney disease, a bleeding disorder, or lung disease.


What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to using Mutamycin® (mitomycin) if you have:
  • Kidney disease, such as kidney failure (renal failure)
  • Liver disease, such as hepatitis, cirrhosis, or liver failure
  • Low platelet counts
  • A bleeding disorder
  • An increased bleeding tendency (you are susceptible to bleeding easily)
  • Lung disease
  • Any allergies, including to medications, foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
You should also tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Precautions and Warnings With Mutamycin

Some warnings and precautions to be aware of prior to receiving this medication include the following:
  • This medicine is associated with potentially serious side effects. It should only be prescribed by a healthcare provider who has experience using chemotherapy medicines, and used in a setting where any potential complications can be appropriately diagnosed and treated.
  • Like other chemotherapy medicines, Mutamycin can decrease the ability of the bone marrow to make blood cells (bone marrow suppression), which can increase your risk for developing life-threatening infections due to low white blood cells, bleeding problems due to low platelets, and anemia due to low red blood cells.
(Click the following articles to learn more about these potentially serious problems and symptoms you should report immediately to your healthcare provider:
  • Mutamycin has been associated with a serious condition known as hemolytic uremic syndrome, which occurs when damaged red blood cells form clots in the small blood vessels of the body, especially the kidneys. People with hemolytic syndrome may develop anemia, abnormal bleeding, and kidney failure. The kidney failure may not be reversible, even if treatment is stopped. Let your healthcare provider know if you develop any signs of this serious condition, such as:
    • Abnormal bleeding or bruising
    • Fatigue
    • Swelling of the hands or feet
    • A decrease in urination.
  • People on Mutamycin must be carefully monitored for potentially serious side effects. Your healthcare provider will use certain blood tests to monitor your blood cell counts during treatment, and for at least eight weeks after your last dose. Make sure to keep all your healthcare and laboratory appointments.
  • There have been reports of breathing problems, including shortness of breath and wheezing, occurring in people who combine vinca alkaloids with Mutamycin (see Mutamycin Drug Interactions).
  • This medicine may increase the risk for life-threatening lung problems. Let your healthcare provider know if you experience difficulty breathing, shortness of breath, or a cough during treatment. He or she may choose to give you additional treatment to help reduce your lung symptoms.
  • This drug is only approved for intravenous use (injection into a vein); however, it is sometimes given though a catheter directly into the bladder when used off-label to treat bladder cancer. There have been reports of bladder spasms occurring when Mutamycin was given in this manner.
  • Mutamycin is a pregnancy Category D medication, which means it may harm your unborn child (see Mutamycin and Pregnancy for more information).
  • It is unknown if Mutamycin passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider before using the medication (see Mutamycin and Breastfeeding).
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Mutamycin Drug Information

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