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Mutamycin Uses

Mutamycin Use for the Treatment of Pancreatic Cancer

Pancreatic cancer starts in the pancreas, a gland that sits behind the stomach and in front of the spine. The pancreas makes digestive juices that help break down food. It also makes hormones, such as insulin and glucagon, which help control blood sugar levels.
The majority of pancreatic cancers begin in the ducts that carry pancreatic juices (the exocrine cells). This type of cancer is also called adenocarcinoma of the pancreas or exocrine pancreatic cancer. Mutamycin is approved to treat this type of cancer too.
Another type of pancreatic cancer begins in the cells that make insulin and other hormones (the endocrine cells). This type of cancer is called pancreatic islet cell cancer or endocrine pancreatic cancer. Endocrine pancreatic cancer occurs much less often than exocrine pancreatic cancer.
Treatment for pancreatic cancer may vary, depending largely on a person's general health and the stage of the cancer (see Stages of Pancreatic Cancer). In general, treatments may include surgery, chemotherapy, and radiation treatment.
Surgery is the only way to cure pancreatic cancer. Unless the disease is found early, however, surgery is unlikely to completely remove it. Other pancreatic cancer treatments may be used to control the disease and to help people live longer and feel better.
Mutamycin is used when the cancer has spread throughout the pancreas or to other areas of the body. It will not cure pancreatic cancer. Instead, it is used as palliative treatment, which means it may help control symptoms or help a person live longer by slowing down the progression of the disease.

How Does This Medicine Work?

Mutamycin works by preventing DNA from replicating. It does this by causing strands of DNA to bind to each other and become linked (known as "cross-linking"). The linked strands are unable to uncoil and separate, which is necessary for the DNA to make copies of itself. If the DNA cannot make copies of itself, cells cannot divide and multiply, which slows down or stops the growth and spread of cancer cells.
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