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Precautions and Warnings With Morphine Sulfate/Naltrexone Hydrochloride

Specific Morphine Sulfate/Naltrexone Hydrochloride Warnings and Precautions

Some warnings and precautions to be aware of prior to taking this drug include the following:
 
  • Morphine sulfate/naltrexone hydrochloride contains tiny, extended-release beads. Do not dissolve, chew, or crush the capsules, as this could release too much medication, causing a potentially fatal overdose. Additionally, this will also release the naltrexone content (which is not normally released), which will counteract the effects of the morphine and may lead to withdrawal symptoms.
     
  • You must not consume any alcohol while taking morphine sulfate/naltrexone hydrochloride, as alcohol can cause the extended-release beads to release too much morphine too quickly, possibly causing a fatal overdose. This includes alcoholic beverages, as well as alcohol in foods and medications.
     
  • Morphine sulfate/naltrexone hydrochloride is a narcotic medication with significant potential for abuse. It is not a good choice for people who have a history of alcohol or drug abuse (see Embeda Abuse). Do not take the drug more frequently, longer, or at a higher dose than prescribed. If you feel you may be developing a problem with morphine sulfate/naltrexone hydrochloride, please seek help from your healthcare provider.
     
  • Morphine sulfate/naltrexone hydrochloride 100 mg/4 mg capsules (the highest strength) should not be used by people unaccustomed to narcotics, as this dosage is much too high.
     
  • The medication can cause problems in people with head injuries or high intracranial pressure. Morphine sulfate/naltrexone hydrochloride should only be used with extreme caution in such circumstances.
     
  • Morphine sulfate/naltrexone hydrochloride can cause slow and irregular breathing. In severe situations, this may lead to life-threatening complications. This may be especially dangerous in people with lung problems.
     
  • Morphine sulfate/naltrexone hydrochloride can cause a decrease in blood pressure, which can be especially dangerous if you already have low blood pressure.
     
  • Narcotics such as morphine sulfate/naltrexone hydrochloride are likely to cause constipation. Usually, laxatives are necessary to treat and prevent constipation due to morphine sulfate/naltrexone hydrochloride (see Embeda and Constipation). Let your healthcare provider know if you develop severe constipation, as this could be a sign of an intestinal blockage.
     
  • Morphine sulfate/naltrexone hydrochloride can interfere with the diagnosis of many conditions that cause severe abdominal (stomach) pain.
     
  • Like any other narcotic, morphine sulfate/naltrexone hydrochloride can cause dizziness and drowsiness, and may increase the risk of falls in elderly people.
     
  • Do not drive or operate heavy machinery until you know how morphine sulfate/naltrexone hydrochloride affects you. Your reflexes and reaction times may be significantly affected, even if you feel fine.
     
  • Check with your healthcare provider before taking the drug if you have hypothyroidism, Addison's disease, an enlarged prostate, epilepsy, gallbladder problems, pancreatic disease, or kidney disease, as morphine sulfate/naltrexone hydrochloride may not be the best choice for you.
     
  • Morphine sulfate/naltrexone hydrochloride can potentially interact with several other medications (see Drug Interactions With Morphine Sulfate/Naltrexone Hydrochloride).
     
  • Morphine sulfate/naltrexone hydrochloride is considered a pregnancy Category C medication. This means that it may not be safe for use during pregnancy, although the full risks are not known (see Embeda and Pregnancy).
     
  • Morphine sulfate/naltrexone hydrochloride passes through breast milk. Therefore, if you are breastfeeding or plan to start breastfeeding, discuss this with your healthcare provider prior to taking the drug (see Embeda and Breastfeeding).
     
Alternative Therapies for Pain Management

Morphine-Naltrexone Drug Information

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