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Drug Interactions With Morphine Sulfate/Naltrexone Hydrochloride

Taking certain medications in combination with morphine sulfate/naltrexone hydrochloride may result in dangerous (and even life-threatening) complications. Some of these drug interactions can increase your risk of side effects, such as difficulty breathing, memory loss, and drowsiness. Alcohol, antihistamines, antipsychotic medications, and barbiturates are among the medications that can lead to negative drug interactions with morphine sulfate/naltrexone hydrochloride.

An Overview of Morphine Sulfate/Naltrexone Hydrochloride Drug Interactions

Morphine sulfate/naltrexone hydrochloride (Embeda™) can potentially interact with a number of other medications. Some of the medicines that may lead to interactions include:



  • Barbiturates, such as:


    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)


  • Benzodiazepines, such as:





  • Muscle relaxants, such as:



  • Monoamine oxidase inhibitors (MAOIs), including:



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Morphine-Naltrexone Drug Information

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