Drug Interactions With Morphine Sulfate ER

Several medications can cause negative drug interactions with morphine sulfate ER, including antihistamines, sleep medications, and antipsychotic medications. These interactions could increase your risk of serious side effects, such as extreme drowsiness, memory loss, and difficulty breathing. To reduce the risk of interactions with morphine sulfate ER, talk to your healthcare provider about any other medications you are taking (including non-prescription medications).

Drug Interactions With Morphine Sulfate ER: An Overview

Morphine sulfate ER (Avinza®, Kadian®, MS Contin®, Oramorph® SR) can potentially interact with a number of other medications. Some of the medicines that may lead to morphine sulfate ER interactions include:
 
  • Alcoholic beverages (or other products that contain alcohol)
  • Alvimopan (Entereg®)
  • Antidepressant medications
  • Antihistamines (including many non-prescription cold, cough, allergy, motion sickness, and sleep medications)
  • Antipsychotics, including (but not limited to):

 

 

  • Barbiturates, such as:

 

    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)

 

  • Benzodiazepine sedatives, such as:

 

 

  • Muscle relaxants, such as:

 

 

  • Monoamine oxidase inhibitors (MAOIs), including:

 

 


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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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