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Drug Interactions With Morphine Sulfate ER

Barbiturates
Combining a barbiturate with morphine sulfate ER can increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Serious side effects may also occur. Talk to your healthcare provider before taking morphine sulfate ER with a barbiturate.
 
Benzodiazepines
Taking morphine sulfate ER in combination with a benzodiazepine might increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Serious side effects may also occur. Talk to your healthcare provider before taking morphine sulfate ER with any benzodiazepine.
 
Monoamine Oxidase Inhibitors (MAOIs)
Combining morphine sulfate ER with an MAOI can cause serious reactions. Do not use morphine sulfate ER and an MAOI within 14 days of each other.
 
Muscle Relaxants
Taking morphine sulfate ER with a muscle relaxant may increase the risk of side effects due to both medications. Check with your healthcare provider before combining morphine sulfate ER with a muscle relaxant.
 
Other Narcotics or Opiates
Use extreme caution when combining morphine sulfate ER with other narcotics or opiates, as serious side effects could occur. You should only use these medications together with your healthcare provider's approval and supervision.
 
Sleep Medications
Morphine sulfate ER can cause significant drowsiness, and combining it with a sleep medication could lead to dangerous effects. In general, morphine sulfate ER should not be used in combination with sleep medications, unless your healthcare provider specifically recommends that you do so.
 

Final Thoughts on Morphine Sulfate ER Drug Interactions

It is possible that not all morphine sulfate ER drug interactions were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about any specific drug interaction that may apply to you.
 
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