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Drug Interactions With Morphine Sulfate ER

Morphine Sulfate ER Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when morphine sulfate ER is combined with any of the drugs listed above.
 
Alcohol
You should avoid alcohol while taking morphine sulfate ER. Alcohol increases the risk of serious side effects, such as extreme drowsiness, confusion, memory loss, or difficulty breathing. Additionally, for most morphine sulfate ER products, consuming any alcohol at all (even small amounts) may cause the medication to release a dangerous amount of morphine too quickly.
 
Alvimopan
Morphine sulfate ER may increase the risk of serious alvimopan side effects. You should not take alvimopan if you have taken morphine sulfate ER for each of the past seven days.
 
Antidepressants
Combining antidepressants with morphine sulfate ER could increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Serious side effects may also occur. Talk to your healthcare provider before taking morphine sulfate ER with an antidepressant, as you may need to be monitored more closely and the dose of your medications may need to be adjusted.
 
Antihistamines
Many antihistamines cause significant drowsiness and can cause serious problems when used in combination with other medications that cause drowsiness, such as morphine sulfate ER. Check with your healthcare provider before taking morphine sulfate ER with an antihistamine, including non-prescription antihistamines. This is probably less of a problem with the newer, "non-sedating" antihistamines.
 
Antipsychotics
Combining an antipsychotic medication with morphine sulfate ER can increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Serious side effects may also occur. Talk to your healthcare provider before taking morphine sulfate ER with an antipsychotic medication.
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