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Using medications such as apomorphine, tramadol, or carbamazepine in combination with Zuplenz may lead to negative drug interactions. Some of these reactions can alter the amounts of the medications in your blood, possibly decreasing the effectiveness of the drugs or causing potentially dangerous side effects. In some cases, your healthcare provider may need to adjust the amount of your dosage.
An Overview of Interactions With ZuplenzZuplenz™ (ondansetron oral soluble film) may potentially react with a number of other medications. Some of the drugs that may lead to interactions with Zuplenz include but are not limited to:
- Apomorphine (Apokyn®)
- Carbamazepine (Carbatrol®, Epitol®, Equetro®, Tegretol®)
- Medications that can cause a heart rhythm change known as QT prolongation (see QT-Prolonging Medications for a list of such medications)
- Phenytoin (Dilantin®, Phenytek®)
- Rifampicin (Rifadin®)
Zuplenz Drug Interactions ExplainedThe following sections explain in detail the potential problems that can occur when Zuplenz is combined with any of the drugs mentioned above.
Taking Zuplenz in combination with apomorphine may cause dangerously low blood pressure (hypotension) and loss of consciousness. These two medications should not be taken together.