Cancer Home > Zortress and Breastfeeding

No research has been done to determine if Zortress (everolimus) passes through breast milk. However, the active ingredient in Zortress has been shown to pass through the breast milk of rats in high amounts. Therefore, women may not be able to take Zortress while breastfeeding, as it may cause serious complications in a nursing infant.

Can Breastfeeding Women Take Zortress?

Zortress® (everolimus) is a prescription anti-rejection medication used to help prevent transplant rejection after a kidney or liver transplant. Transplant rejection occurs when the immune system identifies a transplanted organ as foreign matter and tries to attack it. Zortress works by weakening the immune system, so it cannot attack the transplanted organ.
At this time, it is not known whether Zortress passes through breast milk in humans. The manufacturer of the medication recommends that women avoid breastfeeding while taking Zortress. Therefore, if you are nursing, talk with your healthcare provider prior to taking this medicine.

More Information on Zortress and Breastfeeding

This medication has not been studied in breastfeeding women. However, everolimus (the active ingredient in Zortress) has been studied in lactating animals. In these animal studies, everolimus passed through the breast milk of rats. The level of everolimus in the breast milk was higher than the level observed in the rats' bloodstream.
Currently, all potential problems with Zortress and breastfeeding cannot be ruled out. Because of the possibility that this drug may pass through human breast milk, and the potential for serious side effects in a nursing child, breastfeeding may not be advisable during Zortress treatment.

Talking With Your Healthcare Provider

You should discuss breastfeeding and Zortress use with your healthcare provider. Each woman's situation is different, and you and your healthcare provider understand your situation best. After considering what you want and expect, as well as your current health situation, the two of you can make a shared decision that is right for you.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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