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When diuretics, nonsteroidal anti-inflammatory drugs, vancomycin, or aminoglycoside antibiotics are taken in conjunction with Zometa, drug interactions may potentially occur. These Zometa interactions could increase your risk of low blood calcium and kidney damage, so be sure to talk to your healthcare provider before taking these medications with Zometa.

Zometa Drug Interactions: An Overview

Zometa® (zoledronic acid) can potentially interact with a few different medications. Some of the medicines that may lead to Zometa interactions include:
  • Aminoglycoside antibiotics, such as:
o Amikacin (Amikin®)
o Gentamicin
o Kanamycin (Kantrex®)
o Neomycin (Neo-Fradin®)
o Streptomycin
o Tobramycin
  • Diuretics, such as:
o Triamterene (Dyrenium®) or triamterene/HCTZ (Dyazide®, Maxzide®)
  • Nonsteroidal anti-inflammatory drugs (NSAIDs), such as:
o Ibuprofen (Motrin®, Advil®)
o Ketoprofen (Orudis®)
  • Vancomycin (Vancocin®).
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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