Cancer Home > Zolinza Uses

A healthcare provider may prescribe Zolinza for the treatment of cutaneous T-cell lymphoma when the cancer has not improved, gotten worse, or has come back after treatment with at least two other chemotherapy medications. The drug works by disrupting how the cancer cells multiply. There are also some off-label (unapproved) Zolinza uses, such as treating multiple myeloma or other types of non-Hodgkin's lymphoma.

What Is Zolinza Used For?

Zolinza® (vorinostat) is a prescription medication approved to treat the symptoms of cutaneous T-cell lymphoma. It is reserved for use when this cancer has come back, did not improve, or got worse after treatment with at least two other medicines.

What Is Lymphoma?

Lymphoma is a cancer that occurs when cells in the lymphatic system (part of the body's immune system) become abnormal and grow out of control. The lymphatic system includes lymph nodes, bone marrow, and the spleen. In addition, lymphatic tissue is found in other parts of the body, including the skin. Lymphoma can start almost anywhere this tissue is present.
Lymphoma is generally divided into the following two types:
  • Hodgkin's lymphoma, which is marked by the presence of a type of cell called the Reed-Sternberg cell.
  • Non-Hodgkin's lymphoma, which includes several types of lymphoma that are generally grouped by the type of lymphocyte (a kind of white blood cell) involved. The two main types of lymphocytes are B-cells and T-cells.
Cutaneous T-cell lymphoma is a non-Hodgkin's lymphoma that involves the T-cells found in the skin. It is a broad term that encompasses several different conditions, the most common being mycosis fungoides and Sézary syndrome. People with cutaneous T-cell lymphoma usually have red, itchy, rash-like patches of skin. They may also have tumors on the skin. In some cases, the lymph nodes may be swollen.
Zolinza has been shown to improve skin problems due to cutaneous T-cell lymphoma. It is unknown whether the medicine prolongs survival.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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