Cancer Home > Zolinza Side Effects

Immediate medical treatment may be needed if you are taking Zolinza and develop potentially serious side effects, such as coughing up blood, unusual bleeding, or persistent vomiting. Some of the other possible reactions include fatigue, diarrhea, and weight loss. Your healthcare provider can discuss ways to help prevent or minimize some of these side effects.

An Introduction to Zolinza Side Effects

Just like any chemotherapy medicine, Zolinza® (vorinostat) can cause side effects, some of which can be quite significant. Although not everyone who takes this drug will have problems, most people will experience some type of side effect. Talk to your healthcare provider about ways to prevent or lessen adverse reactions during treatment.
(This article covers many, but not all, of the possible side effects with Zolinza. Your healthcare provider can discuss a more complete list with you.)

Common Side Effects With Zolinza

Zolinza has been studied extensively in clinical trials. In these studies, the side effects that occurred in a group of people given the drug were carefully documented. As a result, it was possible to see what reactions occurred and how often they appeared.
In these studies, the most common Zolinza side effects included:
  • Fatigue -- in up to 52.3 percent of people
  • Diarrhea -- up to 52.3 percent
  • Nausea -- up to 40.7 percent
  • Abnormal taste in the mouth -- up to 27.9 percent
  • Low platelet counts, which could cause abnormal bleeding or bruising -- up to 25.6 percent
  • Decreased appetite -- up to 24.4 percent
  • Weight loss -- up to 20.9 percent
  • Muscle spasms -- up to 19.8 percent
  • Hair loss -- up to 18.6 percent.
Other common reactions, occurring in 10.5 percent to 16.3 percent of people, included:
  • Dry mouth
  • Increase in blood creatinine (found using a blood test)
  • Chills
  • Vomiting
  • Constipation
  • Dizziness
  • Low red blood cells (anemia)
  • Swelling of the arms, hands, legs, ankles, or feet
  • Headache
  • Itching
  • Cough
  • Upper respiratory infections, such as the common cold
  • Fever.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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