Zofran® (ondansetron hydrochloride) is a medication often prescribed to help prevent nausea and vomiting associated with radiation therapy, chemotherapy, and surgery. There are several forms of this drug, including a solution, orally disintegrating tablets, and regular tablets. Zofran is also available as an injection.
Several studies have looked at how well Zofran prevents nausea and vomiting for people undergoing radiation treatments. In studies of people having total body irradiation and daily fractionated radiation, people who took this drug were less likely to have vomiting than people who did not take it.
Zofran for the prevention of vomiting and/or nausea after surgery has been examined in two studies. In these studies, people who took the drug one hour before anesthesia were less likely to have nausea and vomiting compared to people who did not take it.
One study looked at Zofran for chemotherapy regimens that were likely to cause nausea and vomiting; of those who took the drug, 66 percent had no vomiting and 56 percent had no nausea within the first day after chemotherapy.
(Click Zofran for more information on when and how to take this drug, to find out how it works, and to learn about potential side effects.)
Written by/reviewed by: Kristi Monson, PharmD;Arthur Schoenstadt, MD
Last reviewed by: KristiMonson, PharmD;
List of references (click here):
Zofran [package insert]. Research Triangle Park, NC: GlaxoSmithKline;2011 September.
Food and Drug Administration, Center for Drug Evaluation and Research. Electronic orange book: Approved drug products with therapeutic equivalence evaluations. FDA Web site. Available at: http://www.fda.gov/cder/ob/. Accessed January 9, 2007.
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