Cancer Home > Ziv-Aflibercept

Ziv-aflibercept is used for slowing down the growth of colorectal cancer that has spread to other areas of the body. This drug works by cutting off blood supply to the colorectal tumors. A healthcare provider will administer this infusion, which is given as a slow injection into a vein once every two weeks. Side effects may include diarrhea and infections.

What Is Ziv-Aflibercept?

Ziv-aflibercept (Zaltrap®) is a prescription medication approved for use in combination with other drugs to treat metastatic colorectal cancer (cancer of the colon and rectum). Metastatic cancer is cancer that has spread from its original site to other areas of the body.
Ziv-aflibercept is used in combination with the following medications:
  • Leucovorin
  • 5-fluorouracil (Adrucil®, Carac®, Efudex®, Fluoroplex®, also known as 5-FU)
  • Irinotecan (Camptosar®).
It is intended for people whose tumors did not adequately respond to previous treatment that included oxaliplatin (Eloxatin®).
The active ingredient in this drug is ziv-aflibercept, which was previously known simply as aflibercept. It is also the active ingredient in Eyelea® (aflibercept), which is a prescription eye medication used to treat macular degeneration.
(Click What Is Ziv-Aflibercept Used For? for more information on this topic, including possible off-label uses.)

Are There Side Effects?

Just like any chemotherapy medicine, ziv-aflibercept can cause side effects, some of which can be significant and potentially serious. In fact, most people will experience some type of side effect during treatment. Talk with your healthcare provider about ways to prevent or lessen reactions to this drug.
Some of the more common side effects seen with ziv-aflibercept include but are not limited to:
  • A decrease in white blood cell counts, which increases the risk for infections
  • Diarrhea
  • An increase in protein in the urine
  • Increased liver enzymes
  • Mouth sores and inflammation.
(Click Ziv-Aflibercept Side Effects to learn more, including potentially serious side effects you should report immediately to your healthcare provider.)
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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