Cancer Home > Drug Interactions With Vismodegib
More Detail on Drug Interactions With VismodegibThe following sections explain in detail the potentially negative interactions that can occur when vismodegib is combined with any of the drugs listed above.
Taking antacids with vismodegib may decrease the amount of vismodegib absorbed into your bloodstream, which could potentially decrease its effectiveness. Talk to your healthcare provider before taking an antacid during treatment.
Vismodegib may increase blood levels of certain antidepressants, which could increase the risk for side effects. Talk to your healthcare provider before combining vismodegib with any of the antidepressants listed above.
Certain Medications Used to Treat Diabetes
Combining vismodegib with the medications listed above to treat diabetes could increase the blood level of the diabetes medicine, potentially increasing your risk for side effects, including low blood sugar levels. Your healthcare provider may recommend you check your blood sugar levels more often if you take these drugs together.
Taking H2 blockers with vismodegib may decrease the amount of vismodegib absorbed into your bloodstream, possibly decreasing its effectiveness. Talk to your healthcare provider before taking these drugs together.
P-glycoprotein (Pgp) Inducers
P-glycoprotein is a protein found in the body. One of its roles is to help remove substances, such as medications, from the tissues in the body so they can be excreted through the urine or feces. Pgp helps remove vismodegib from the body, and certain medications called Pgp inducers increase the activity of Pgp.
Thus, taking vismodegib with one of these drugs causes vismodegib to be removed from the body too quickly, which could make the medicine less effective. Talk to your healthcare provider before taking these medications together.