Cancer Home > Vemurafenib

Drug Interactions

Vemurafenib may react with a number of other medicines (see Drug Interactions With Vemurafenib).

What If I Overdose on This Medicine?

At this time, it is not entirely clear what to expect from an overdose with vemurafenib. It is important to seek immediate medical attention if you or someone else may have overdosed on this or any other medication.
(Click Zelboraf Overdose for more information.)

What If I Miss a Dose of Vemurafenib?

If you forget a dose of vemurafenib, simply take the missed dose as soon as you remember, unless it is less than four hours until your next scheduled dose. In this case, skip the missed dose, and continue with your regular schedule. Do not take two doses of this medication at the same time to make up for a missed dose.

How Does This Medicine Work?

Vemurafenib is approved for use in people who have an abnormal gene known as the BRAF gene. The BRAF protein helps regulate cell growth. When the BRAF gene is abnormal, the BRAF protein is constantly turned on, causing an abnormal growth of cells, which leads to melanoma.
Vemurafenib works by blocking the action of the BRAF protein, and thus preventing abnormal cell growth. By blocking abnormal cell growth, vemurafenib can slow down the progression of melanoma.

Clinical Effects

Vemurafenib has been shown to improve survival time and delay progression of advanced melanoma in people who have not already received treatment. Everyone in the clinical study had a mutation in the BRAF gene, which is associated with melanoma.
In the study, people given vemurafenib had a progression-free survival (which is the amount of time after treatment starts that the cancer does not get worse) of about 5.3 months, compared to 1.6 months in people given a different cancer medication.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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