Cancer Home > Trexall Uses

The primary reasons for using Trexall are to treat certain types of cancer and severe cases of psoriasis and rheumatoid arthritis in adults. Typically, the medication is recommended for people who must take large doses at a single time. Trexall comes in higher strengths than other methotrexate tablets, which makes it more convenient. The drug is also approved for cancer treatment in children.

An Overview of Uses for Trexall

Trexall™ (methotrexate) is a prescription medication used for the following conditions:
 
Because Trexall comes in higher strengths (5 mg, 7.5 mg, 10 mg, and 15 mg) compared to other methotrexate tablets (2.5 mg), it is more useful for people who take large doses at a single time.
 
Because Trexall can cause serious side effects, it is important to make sure other, less toxic medications have been tried first, if appropriate. Your healthcare provider will need to monitor you carefully, with frequent blood tests to check your kidney function, liver function, and blood cell counts. Chest x-rays may also be recommended to check for side effects that involve the lungs.
 

How Does Trexall Work?

This medication works by inhibiting an enzyme known as dihydrofolic acid reductase (also known as dihydrofolate reductase). This enzyme is important for transforming an inactive form of folic acid into the active form, which is necessary to make some of the building blocks needed for DNA production. By inhibiting this enzyme, Trexall interferes with a cell's ability to repair and replicate (copy) itself.
 
Although this drug can damage healthy cells as well as unhealthy cells, it tends to target rapidly replicating cells, such as cancer cells and bone marrow cells.
 
It is not entirely clear how Trexall works for treating rheumatoid arthritis, although it is thought to work by affecting the immune system.
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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